Carbonyl Condensations

Aldol, Claisen & Michael at Full Power

Turn enolate chemistry into synthesis power. Control crossed and directed aldols, close rings with Dieckmann and intramolecular aldol condensations, build acids and methyl ketones with the malonic and acetoacetic ester syntheses, and assemble cyclohexenones with Michael additions, Stork enamines, and the Robinson annulation.

Estimated time: ~3 hours